A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

Bipolar affective disorder (BPAD) can be a devastating disorder for both sufferers and their relatives. In addition to the variety of distressing and severe affective symptoms, the consequences of illness onset may be equally debilitating, particularly as the illness may commonly present in early adulthood. As such, the developmental trajectory between late adolescence and early adulthood is commonly interrupted. Relationships with family, friends and partners may deteriorate, employment or studies may be interrupted, and criminal histories may be acquired. In turn, (...) such events worsen stress, reduce self-esteem, and may make the recovery process more difficult.... (shrink)

Catalan translation, introductory study and notes on W. K. Clifford’s “The Ethics of Belief”. Published in Clifford, W.K. “L’ètica de la creença”. Quaderns de Filosofia, vol. III, n. 2 (2016), pp. 129–150. // Catalan translation, introductory study and notes on William James’s “The Will to Believe”. Published in James, William. “La voluntat de creure”. Quaderns de Filosofia, vol. III, n. 2 (2016), pp. 151–172. [Introductory study published in Oya, Alberto. “Introducció. El debat entre W. K. Clifford i William James”. Quaderns (...) de Filosofia, vol. III, n. 2 (2016), pp. 123–127]. (shrink)

Since the early 1980’s, with the clinical advent of in vitro fertilization resulting in so-called “test tube babies,” a wide array of ethical considerations and concerns regarding artificial womb technology (AWT) have been described. Recent breakthroughs in the development of extracorporeal neonatal life support by means of AWT have reinitiated ethical interest about this topic with a sense of urgency. Most of the recent ethical literature on the topic, however, pertains not to the more imminent scenario of a physiologically improved (...) method of neonatal care through AWT, but instead to the remote scenario of “complete ectogenesis” that imagines human gestation occurring entirely outside of the womb. This scoping review of the ethical literature on AWT spans from more abstract concerns about complete ectogenesis to more immediate concerns about the soon-to-be-expected clinical life support of what we term the fetal neonate or fetonate. Within an organizing framework of different stages of human gestational development, from conception to the viable premature infant, we discuss both already identified and newly emerging ethical considerations and concerns regarding AWT and the care of the fetonate. (shrink)

Treatise on political power, statecraft, and the qualities of the ideal ruler.

With an new foreword by James Warren Long renowned as one of the clearest and best introductions to ancient Greek philosophy for non-specialists, W.K.C Guthrie s The Greek Philosophers offers us a brilliant insight into the hidden foundations of Greek philosophy foundations that underpin Western thought today. Guthrie explores the great age of Greek Philosophy from Thales to Aristotle whilst combining comprehensiveness with brevity. He unpacks the ideas and arguments of Plato and Aristotle in the light of their predecessors rather (...) than their successors and describes the characteristic features of the Greek way of thinking, emphasising what he calls the cultural soil of their ideas. He also highlights the achievements of thinkers such as Pythagoras, who in contemporary accounts of Greek philosophy are frequently overlooked. Combining philosophical insight and historical sensitivity, The Greek Philosophers offers newcomers a brilliant introduction to the greatest thinkers in ancient Greek philosophy and the very origins of Western thought. ". (shrink)

The third volume of Professor Guthrie's great history of Greek thought, entitled The Fifth-Century Enlightenment, deals in two parts with the Sophists and Socrates, the key figures in the dramatic and fundamental shift of philosophical interest from the physical universe to man. Each of these parts is now available as a paperback with the text, bibliography and indexes amended where necessary so that each part is self-contained. The Sophists assesses the contribution of individuals like Protagoras, Gorgias and Hippias to the (...) extraordinary intellectual and moral fermant in fifth-century Athens. They questioned the bases of morality, religion and organized society itself and the nature of knowledge and language; they initiated a whole series of important and continuing debates, and they provoked Socrates and Plato to a major restatement and defence of traditional values. (shrink)

All volumes of Professor Guthrie's great history of Greek philosophy have won their due acclaim. The most striking merits of Guthrie's work are his mastery of a tremendous range of ancient literature and modern scholarship, his fairness and balance of judgement and the lucidity and precision of his English prose. He has achieved clarity and comprehensiveness.

Cognitive Science, Volume 46, Issue 6, June 2022.

Background: In 2014, companies began covering the costs of egg freezing for their employees. The adoption of this benefit was highly contentious. Some argued that it offered women more reproductive...

It would therefore be reasonable to undertake a description and appreciation of this book precisely in its character as a dialectical dictionary or magazine of aesthetic issues and arguments. One could conduct a guided tour, stopping to admire the fullness of information, or fertility of invention, and the nicely graded series of the ideas collected in this locus or that, or in some area where one happened to be well enough informed, noting the omissions. One might even raise a theoretical (...) question about this whole aspect of the work, starting with the author's bald assertion: "What I have written is, simply and literally, a guide to aesthetics—a guide to the structure and problems of the subject, not to its literature." His "approach," he says, "is systematic, not historical." He "mentions names," but he says he is "not concerned much with who first said what," and his references are not always to the "earliest or best exponents of the views they illustrate". Much of the literature he says he has not read and does not mean to read. One who has himself not read all of the aesthetic literature can hardly object to this very strenuously. (shrink)

The third volume of Professor Guthrie's great history of Greek thought, entitled The Fifth-Century Enlightenment, deals in two parts with the Sophists and Socrates, the key figures in the dramatic and fundamental shift of philosophical interest from the physical universe to man. Each of the two parts is available as a paperback with the text, bibliography and indexes amended where necessary so that each part is self-contained. Socrates dominated the controversies of this period, as he has dominated the subsequent history (...) of western philosophy. He was the first to identify and grapple with some of the most intractable and persistent logical and philosophical problems; but he was also and has remained a highly controversial figure because of his extraordinary personal qualities and his remarkable career. Professor Guthrie offers a balanced and comprehensive picture of the man, his life, and his thought. (shrink)

Despite more than 25 years of a requirement for training in the responsible conduct of research, there is still little consensus about what such training should include, how it should be delivered, nor what constitutes “effectiveness” of such training. This lack of consensus on content, approaches and outcomes is evident in recent data showing high variability in the development and implementation of RCR instruction across universities and programs. If we accept that one of the primary aims of instruction in RCR/research (...) ethics is “to foster a community of social responsibility”, then it makes sense to consider the research environment itself—where learning one’s science happens where one also engages in social interaction around that science. In order to take the best advantage of that already existing/naturally occurring research environment, the authors, through a deliberative, collaborative, and integrative process, crafted a workshop curriculum meant to arm research faculty with concrete and specific tools to effectively introduce research ethics in the context of the research environment. (shrink)

We explore how principles predicting the success of a medical information commons advantaged or disadvantaged three MIC initiatives in three Canadian provinces. Our MIC case examples demonstrate that practices and policies to promote access to and use of health information can help improve individual healthcare and inform a learning health system. MICs were constrained by heterogenous health information protection laws across jurisdictions and risk-averse institutional cultures. A networked approach to MICs would unlock even more potential for national and international data (...) collaborations to improve health and healthcare. (shrink)

R W K Paterson; Towards an Axiology of Knowledge, Journal of Philosophy of Education, Volume 13, Issue 1, 30 May 2006, Pages 91–100, https://doi.org/10.1111/j.1.